Cucurbiturils: from synthesis to high-affinity binding and catalysis

KI Assaf, WM Nau - Chemical Society Reviews, 2015 - pubs.rsc.org
In the wide area of supramolecular chemistry, cucurbit [n] urils (CBn) present themselves as
a young family of molecular containers, able to form stable complexes with various guests …

Supramolecular prodrugs based on host–guest interactions

WC Geng, JL Sessler, DS Guo - Chemical Society Reviews, 2020 - pubs.rsc.org
Classic prodrug strategies rely on covalent modification of active drugs to provide systems
with superior pharmacokinetic properties than the parent drug and facilitate administration …

Applications of cucurbiturils in medicinal chemistry and chemical biology

D Das, KI Assaf, WM Nau - Frontiers in chemistry, 2019 - frontiersin.org
The supramolecular chemistry of cucurbit [n] urils (CB n) has been rapidly developing to
encompass diverse medicinal applications, including drug formulation and delivery …

Cucurbituril chemistry: a tale of supramolecular success

E Masson, X Ling, R Joseph, L Kyeremeh-Mensah… - Rsc Advances, 2012 - pubs.rsc.org
This review highlights the past six year advances in the blossoming field of cucurbit [n] uril
chemistry. Because of their exceptional recognition properties in aqueous medium, these …

Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals

D Ma, G Hettiarachchi, D Nguyen, B Zhang… - Nature …, 2012 - nature.com
Abstract The solubility characteristics of 40–70% of new drug candidates are so poor that
they cannot be formulated on their own, so new methods for increasing drug solubility are …

The strategic use of supramolecular pKa shifts to enhance the bioavailability of drugs

I Ghosh, WM Nau - Advanced drug delivery reviews, 2012 - Elsevier
Macrocyclic hosts of the cyclodextrin, sulfonatocalixarene, and cucurbituril type can be
employed as discrete supramolecular drug delivery systems, thereby complementing …

Toxicity of cucurbit [7] uril and cucurbit [8] uril: an exploratory in vitro and in vivo study

VD Uzunova, C Cullinane, K Brix, WM Nau… - Organic & biomolecular …, 2010 - pubs.rsc.org
Cucurbit [n] urils (CB [n]) are potential stabilizing, solubilizing, activating, and delivering
agents for drugs. The toxicity of the macrocyclic host molecules cucurbit [7] uril (CB [7]), the …

Supramolecular polymeric biomaterials

JL Mann, CY Anthony, G Agmon, EA Appel - Biomaterials science, 2018 - pubs.rsc.org
Polymeric chains crosslinked through supramolecular interactions—directional and
reversible non-covalent interactions—compose an emerging class of modular and tunable …

Metal–organic polyhedron capped with cucurbit [8] uril delivers doxorubicin to cancer cells

SK Samanta, D Moncelet, V Briken… - Journal of the American …, 2016 - ACS Publications
Self-assembly of ligand 1 and Pd (NO3) 2 delivers Fujita-type metal–organic polyhedron
(MOP) 3 which bears 24 covalently attached methyl viologen units on its external surface, as …

Cucurbit [7] uril enables multi-stimuli-responsive release from the self-assembled hydrophobic phase of a metal organic polyhedron

SK Samanta, J Quigley, B Vinciguerra… - Journal of the …, 2017 - ACS Publications
Mixed self-assembly of ligands 1, 2, 1, 6-hexanediamine (HDA), and Pd (NO3) 2 afforded
Fujita-type metal organic polyhedron MOP1 (diameter≈ 8.2 nm), which is covalently …