Cancer has become a grave health crisis that threatens the lives of millions of people
worldwide. Because of the drawbacks of the available anticancer drugs, the development of …

The demand for discovering novel microbial secondary metabolites is growing to address
the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and …

Abstract Filamentous Actinobacteria, recently renamed Actinomycetia, are the most prolific
source of microbial bioactive natural products. Studies on biosynthetic gene clusters benefit …

For decades, natural products have been used as a primary resource in drug discovery
pipelines to find new antibiotics, which are mainly produced as secondary metabolites by …

Streptomyces species are best known for their ability to produce abundant secondary
metabolites with versatile bioactivities and industrial importance. These metabolites are …

Isoquinolinequinones represent an important family of natural alkaloids with profound
biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase …

As bacterial natural products have been proved to be the most important source of many
therapeutic medicines, the need to discover novel natural products becomes extremely …

Here, we describe two N-acetyl-cysteinylated streptophenazines (1 and 2) produced by the
soil-derived Streptomyces sp. ID63040 and identified through a metabolomic approach …

Marine microbes genetically evolved to survive varying salinity, temperature, pH, and other
stress factors by producing different bioactive metabolites. These microbial secondary …

In the post-genome era, great progress has been made in metabolic engineering using
recombinant DNA technology to enhance the production of high-value products by …