For people living in a typical hunter-gatherer population, sodium is scarce, and hypertension
is rare. 15 They are in a critical sodium balance, and any minor defect in sodium …

Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …

Hypertension is one of the strongest modifiable cardiovascular risk factors, affecting an
increasing number of people worldwide. Apart from poor medication adherence, the low …

Hypertension is the leading cause of cardiovascular disease in the United States, affecting
up to one-third of adults. When compared to other ethnic or racial groups in the United …

Hypertension is a multifactorial disease that affects approximately one billion subjects
worldwide and is a major risk factor associated with cardiovascular events, including …

Cardiovascular and renal diseases are associated with many risk factors, of which
hypertension is one of the most prevalent. Worldwide, blood pressure control is only …

The main goal of treating hypertension is to reduce blood pressure to physiological levels
and thereby prevent risk of cardiovascular disease and hypertension-associated target …

Low health literacy is associated with poor clinical outcomes. The relationship between
literacy and blood pressure (BP) has been inconsistent. We investigated the determinants of …

Ion channels and transporters play a critical role in ion and fluid homeostasis and thus in
normal animal physiology and pathology. Tight regulation of these transmembrane proteins …

Nedd4-2 is a ubiquitin ligase previously demonstrated to regulate endocytosis and
lysosomal degradation of the epithelial Na+ channel (ENaC) and other ion channels and …