Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …

Directional cell movement through tissues is critical for multiple biological processes and
requires maintenance of polarity in the face of complex environmental cues. Here we use …

To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-
carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal …

Cell migration is essential for the development and maintenance of multicellular organisms,
contributing to embryogenesis, wound healing, immune response, and other critical …

The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum
(ER) and endosomes, respectively—are connected through contact sites whose numbers …

Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and
two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first …

Inflammation is a central feature of an effective immune response, which functions to
eliminate pathogens and other foreign material, and promote recovery; however …

Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …