Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Background Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3,
modulate cell growth and survival, and are thought to be important in tumour development …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

The insulin-like growth factor (IGF) system is an evolutionarily conserved signaling pathway
that is composed of two IGF ligands, two IGF receptors, and six IGF binding proteins. Studies …

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the
IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent …

The six members of the insulin-like growth factor-binding protein family (IGFBP-1–6) are
important components of the IGF (insulin-like growth factor) axis. In this capacity, they serve …

Progesterone receptors (PRs) are prognostic markers in breast cancers irrespective of the
patient's progestational status. However, there are two PR isoforms, PR-A and PR-B, that are …

The neoplastic production of the insulin-like growth factor binding protein (IGFBP)-2 often
correlates with tumor malignancy and aggressiveness. Since IGFBP-2 contains an RGD …