The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Animals discriminate stimuli, learn their predictive value and use this knowledge to modify
their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes …

Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …

Sleep remains one of the least understood phenomena in biology—even its role in synaptic
plasticity remains debatable. Since sleep was recognized to be regulated genetically …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct
sleep deficits remain unknown. Here, we report that sleep-promoting neurons with …

The functions of sleep remain elusive, but a strong link exists between sleep need and
neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a …

Sleep is nearly ubiquitous throughout the animal kingdom, yet little is known about how
ecological factors or perturbations to the environment shape the duration and timing of …