After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Abstract Importance More than 109,000 Americans died of drug overdose in 2022, with
81,231 overdose deaths involving opioids. Methadone, buprenorphine and naltrexone are …

Opioids are widely used in chronic pain management, despite major concerns about their
risk of adverse events, particularly abuse, misuse, and respiratory depression from …

The cation channel of sperm (CatSper) is a validated target for nonhormonal male
contraception, but it lacks selective blockers, hindering studies to establish its role in both …

Long-acting buprenorphine formulations have been recently marketed for the Opioid Agonist
Treatment (OAT) of opioid use disorder (OUD) associated with medical, social, and …

Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of
diseases, and significantly affects daily functioning. Cardiovascular adverse effects of …

Pain management in palliative care (PC) is becoming more complex as patients survive
longer with life-limiting illnesses and population-wide trends involving opioid misuse …

Transdermal buprenorphine is indicated for chronic pain management, but as its role in the
clinical management of acute pain is less clear, this narrative review examines studies of the …

Buprenorphine (BUP) is a commonly prescribed medication for the treatment of opioid use
disorder (OUD). As prescriptions increase in North Carolina, BUP is more frequently …