Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Tuberculosis and HIV co-infection

A Pawlowski, M Jansson, M Sköld… - PLoS …, 2012 - journals.plos.org
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems
and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most …

T cells and adaptive immunity to Mycobacterium tuberculosis in humans

LD Jasenosky, TJ Scriba, WA Hanekom… - Immunological …, 2015 - Wiley Online Library
The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Tuberculosis and HIV coinfection

J Bruchfeld, M Correia-Neves… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency
syndrome (HIV/AIDS) constitute the main burden of infectious disease in resource-limited …

HIV/Mtb co-infection: from the amplification of disease pathogenesis to an “emerging syndemic”

JM Azevedo-Pereira, D Pires, M Calado, M Mandal… - Microorganisms, 2023 - mdpi.com
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons

H Esmail, C Riou, E du Bruyn, RPJ Lai… - Annual review of …, 2018 - annualreviews.org
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …

New anti-tuberculosis drugs in clinical trials with novel mechanisms of action

EC Rivers, RL Mancera - Drug Discovery Today, 2008 - Elsevier
Tuberculosis is a major health problem worldwide, with approximately 1.7 million people
dying annually from the disease. The long current drug regimen, the emergence of drug …

Chronic immune activation in TB/HIV co-infection

R Sharan, AN Bucşan, S Ganatra, M Paiardini… - Trends in …, 2020 - cell.com
HIV co-infection is the most critical risk factor for the reactivation of latent tuberculosis (TB)
infection (LTBI). While CD4+ T cell depletion has been considered the major cause of HIV …

HIV–Mycobacterium tuberculosis co-infection: a 'danger-couple model' of disease pathogenesis

EM Shankar, R Vignesh, R Ellegård… - Pathogens and …, 2014 - academic.oup.com
Tuberculosis (TB) and human immunodeficiency virus (HIV) infection interfere and impact
the pathogenesis phenomena of each other. Owing to atypical clinical presentations and …

Chemokines shape the immune responses to tuberculosis

SR Slight, SA Khader - Cytokine & growth factor reviews, 2013 - Elsevier
Mycobacterium tuberculosis (Mtb) is the intracellular pathogen that causes the disease,
tuberculosis. Chemokines and chemokine receptors are key regulators in immune cell …