Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies

NS Nielsen, ET Poulsen, MV Lukassen… - Progress in Retinal and …, 2020 - Elsevier
Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Transcriptomic analysis of differential gene expression during chick periocular neural crest differentiation into corneal cells

L Bi, P Lwigale - Developmental Dynamics, 2019 - Wiley Online Library
Background Multipotent neural crest cells (NCC) contribute to the corneal endothelium and
keratocytes during ocular development, but the molecular mechanisms that underlie this …

The serine protease HtrA1 cleaves misfolded transforming growth factor β–induced protein (TGFBIp) and induces amyloid formation

ET Poulsen, NS Nielsen, C Scavenius… - Journal of Biological …, 2019 - ASBMB
The serine protease high-temperature requirement protein A1 (HtrA1) is associated with
protein-misfolding disorders such as Alzheimer's disease and transforming growth factor β …

Mutation-induced dimerization of transforming growth factor-β–induced protein may drive protein aggregation in granular corneal dystrophy

NS Nielsen, TAF Gadeberg, ET Poulsen… - Journal of Biological …, 2021 - ASBMB
Protein aggregation in the outermost layers of the cornea, which can lead to cloudy vision
and in severe cases blindness, is linked to mutations in the extracellular matrix protein …

Transcriptional Profiles of Differentiating Periocular Neural Crest Cells and the Function of Nephronectin during Chick Corneal Development

L Bi - 2020 - search.proquest.com
During eye formation, periocular neural crest cells (pNC) migrate and differentiate to form
the anterior ocular structures. In the chick cornea, this involves two waves of migration that …

[PDF][PDF] Trastornos del colágeno y sus implicaciones oculares. revisión de tema

AJ Hernández Sandoval - 2018 - repositorio.unisinucartagena.edu.co
Primeramente quisiera dar gracias a Dios por permitirme obtener tan linda y buena
experiencia en mi universidad, a mis asesores de trabajo, el Dr. Carlos Alfonso Rojas y la …