Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern
with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This …

A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Small heat shock proteins (sHsps) belong to the family of heat shock proteins (Hsps): some
are induced in response to multiple stressful events to protect the cells while others are …

Following central nervous system (CNS) demyelination, adult oligodendrocyte progenitor
cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative …

Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction
and is likely a causative factor in the pathogenesis of age-related macular degeneration …

Background αA-and αB crystallins are principal members of the small heat shock protein
family and elicit both a cell protective function and a chaperone function. α-Crystallins have …

Thioflavin T derivatives are used in positron-emission tomography (PET) studies to detect
amyloid protein deposits in patients with Alzheimer disease. These tracers bind extensively …

α-Crystallin is a member of the small heat-shock protein (sHSP) family and consists of two
subunits, αA and αB. Both αA-and αB-crystallin act as chaperones and anti-apoptotic …

Abstract αB-crystallin, also called HspB5, is a molecular chaperone able to interact with
unfolding proteins. By interacting, it inhibits further unfolding, thereby preventing protein …

Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12
and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to …