In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

In the process of bone regeneration, new bone formation is largely affected by physico-
chemical cues in the surrounding microenvironment. Tissue cells reside in a complex …

Significant efforts have been directed to understanding the factors that influence the lineage
commitment of stem cells. This paper demonstrates that cell shape, independent of soluble …

In the body, cells encounter a complex milieu of signals, including topographical cues, in the
form of the physical features of their surrounding environment. Imposed topography can …

In biological systems, form and function are inherently correlated. Despite this strong
interdependence, the biological effect of curvature has been largely overlooked or …

The design of artificial extracellular matrix (ECM) is important in tissue engineering because
artificial ECM regulates cellular behaviors, including proliferation, survival, migration, and …

Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Motile cells—fan-like keratocytes, hand-shaped nerve growth cones, polygonal fibroblasts,
to name but a few—come in different shapes and sizes. We discuss the origins of this …

Shape is an indicator of cell health. But how is the information in shape decoded? We
hypothesize that decoding occurs by modulation of signaling through changes in plasma …

Extracellular matrices (ECMs) are challenging design targets for materials synthesis
because they serve multiple biological roles, and they are composed of multiple molecular …