T Kawai, MV Autieri, R Scalia - American Journal of …, 2021 - journals.physiology.org
Several lines of preclinical and clinical research have confirmed that chronic low-grade inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …
K Aleksandrova, L Koelman, CE Rodrigues - Redox biology, 2021 - Elsevier
Introduction Oxidative stress and inflammation are known to play a critical role in ageing and chronic disease development and could therefore represent important targets for developing …
E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degradation but also synovial membrane inflammation, osteophyte formation and …
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
V Abella, M Scotece, J Conde, J Pino… - Nature Reviews …, 2017 - nature.com
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …
L Marseglia, S Manti, G D'Angelo, A Nicotera… - International journal of …, 2014 - mdpi.com
Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and …
Abstract The American Medical Association recently recognized obesity as both an illness and a leading cause of preventable death and chronic disease. This association is not only …
M Sánchez-de-la-Torre… - The Lancet …, 2013 - thelancet.com
Obstructive sleep apnoea (OSA) is a common health concern caused by repeated episodes of collapse of the upper airway during sleep. The events associated with OSA lead to brain …
V Abella, M Scotece, J Conde, R Gómez, A Lois… - Biomarkers, 2015 - Taylor & Francis
Abstract Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic …