The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

The integrity of the plasma membranes is extremely crucial for the survival and proper
functioning of the cells. Organisms from all kingdoms of life employ specialized pore-forming …

The cytoplasmic membrane is one of the most frequent cell targets of antimicrobial peptides
(AMPs) and other biomolecules. Understanding the mechanism of action of AMPs at the …

Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

In 2020, the WHO established the road map for neglected tropical diseases 2021–2030,
which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas …

Pore-forming protein toxins (PFTs) represent a diverse class of membrane-damaging
proteins that are produced by a wide variety of organisms. PFT-mediated membrane …

Highlights•PFPs are fundamental defense and virulence factors in bacteria and as executors
of regulated cell death in eukaryotic cells.•Proteins and lipids cooperate to form different …

Proteins and peptides with hydrophobic and amphiphilic segments are responsible for many
biological functions. The sensing and generation of membrane curvature are the functions of …

Actinoporins constitute a family of α pore-forming toxins produced by sea anemones. The
soluble fold of these proteins consists of a β-sandwich flanked by two α-helices. Actinoporins …

Leishmaniasis, a category I neglected tropical disease, is a group of diseases caused by the
protozoan parasite Leishmania species with a wide range of clinical manifestations. Current …