Synthetic glucocorticoids are widely used for their anti-inflammatory and
immunosuppressive actions. A possible unwanted effect of glucocorticoid treatment is …

The rapidly increasing prevalence of both obesity and depression represent two major
public health concerns worldwide. But the evidence regarding the direction and strength of …

Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The characterization of the subfamily of steroid hormone receptors has enhanced our
understanding of how a set of hormonally derived lipophilic ligands controls cellular and …

Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance,
glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the …

Most actions of glucocorticoids (GCs) are mediated by the glucocorticoid receptor (GR). The
interindividual response to GCs varies considerably, as demonstrated by a variable …

Background and aim Epidemiological data has established increasing adiposity as a risk
factor for incident asthma. However, the mechanisms underlying the association between …

The glucocorticoid receptor is a member of the nuclear receptor family that controls many
distinct gene networks, governing various aspects of development, metabolism …

The glucocorticoid receptor (GR) is crucial for the effects of glucocorticoids (GCs). Several
polymorphisms of the GR are associated with altered sensitivity to GCs. For the ER22/23EK …