Major depressive disorder (MDD) is a psychiatric condition that affects a large number of
people in the world, and the treatment existents do not work for all individuals affected. Thus …

The molecular mechanisms underlying major depressive disorder remain poorly
understood, and current antidepressant treatments have many shortcomings. The recent …

Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

In order to expand the prospects of developing novel antidepressants for treatment-resistant
populations, animal models should incorporate not only various stress-induced behavioural …

Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could
be associated with the pathophysiology of depression. This study investigated the markers …

Significant stress exposure and psychiatric depression are associated with morphological,
biochemical, and physiological disturbances of astrocytes in specific brain regions relevant …

Mitochondrial and cognitive dysfunctions have long been associated with major depressive
disorders (MDDs). Studies have shown that Memantine, an N-methyl-D-aspartate (NMDA) …

Background Major depressive disorder (MDD) is characterized by increased oxidative and
nitrosative stress. We compared nitric oxide metabolism, ie, the global arginine …

Background: Many studies have been shown an important role of glutamatergic system as
well microglial activation in the pathophysiology of major depressive disorder (MDD). In …