Metal toxicity links to Alzheimer's disease and neuroinflammation
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
disease (AD) and the associated socio-economic burden are predicted to worsen. While …
[HTML][HTML] Pros and cons of ultra-high-field MRI/MRS for human application
Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …
for clinical diagnostic applications and in basic research areas such as cognitive …
The use of neuroimaging techniques in the early and differential diagnosis of dementia
L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …
disease modifying treatment for any of the most common types of dementia such as …
Biological metals and metal-targeting compounds in major neurodegenerative diseases
KJ Barnham, AI Bush - Chemical Society Reviews, 2014 - pubs.rsc.org
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …
Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline
Abstract See Derry and Kent (doi: 10.1093/awx167) for a scientific commentary on this
article. The large variance in cognitive deterioration in subjects who test positive for amyloid …
article. The large variance in cognitive deterioration in subjects who test positive for amyloid …
Ultra-high-field MR neuroimaging
P Balchandani, TP Naidich - American Journal of …, 2015 - Am Soc Neuroradiology
At ultra-high magnetic fields, such as 7T, MR imaging can noninvasively visualize the brain
in unprecedented detail and through enhanced contrast mechanisms. The increased SNR …
in unprecedented detail and through enhanced contrast mechanisms. The increased SNR …
Cortical iron reflects severity of Alzheimer's disease
S van Duijn, M Bulk, SG van Duinen… - Journal of …, 2017 - content.iospress.com
Abnormal iron distribution in the isocortex is increasingly recognized as an in vivo marker for
Alzheimer's disease (AD). However, the contribution of iron accumulation to the AD …
Alzheimer's disease (AD). However, the contribution of iron accumulation to the AD …
Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early-and late-onset Alzheimer's disease
M Bulk, WM Abdelmoula, RJA Nabuurs… - Neurobiology of …, 2018 - Elsevier
Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to
late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron …
late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron …
[HTML][HTML] Cortical iron accumulation as an imaging marker for neurodegeneration in clinical cognitive impairment spectrum: a quantitative susceptibility mapping study
Objective Cortical iron deposition has recently been shown to occur in Alzheimer's disease
(AD). In this study, we aimed to evaluate how cortical gray matter iron, measured using …
(AD). In this study, we aimed to evaluate how cortical gray matter iron, measured using …
Distribution of iron, copper, zinc and cadmium in glia, their influence on glial cells and relationship with neurodegenerative diseases
A Górska, A Markiewicz-Gospodarek, R Markiewicz… - Brain Sciences, 2023 - mdpi.com
Recent data on the distribution and influence of copper, zinc and cadmium in glial cells are
summarized. This review also examines the relationship between those metals and their …
summarized. This review also examines the relationship between those metals and their …