Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
T Herdegen, JD Leah - Brain research reviews, 1998 - Elsevier
This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …
JNK signalling: a possible target to prevent neurodegeneration
T Borsello, G Forloni - Current pharmaceutical design, 2007 - ingentaconnect.com
The c-Jun N-terminal kinases (JNK) belong to the subfamily of mitogen-activated protein
kinase (MAPK). JNK is an important transducing enzyme that is involved in many facets of …
kinase (MAPK). JNK is an important transducing enzyme that is involved in many facets of …
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and …
H Sauer, WH Oertel - Neuroscience, 1994 - Elsevier
In order to develop a rodent model displaying a progressive degeneration of the dopamine
neurons of the substantia nigra, we bilaterally injected the tracer substance FluoroGold into …
neurons of the substantia nigra, we bilaterally injected the tracer substance FluoroGold into …
Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
A Björklund, C Rosenblad, C Winkler, D Kirik - Neurobiology of disease, 1997 - Elsevier
Intrastriatal 6-hydroxydopamine injections in rats induce partial lesions of the nigrostriatal
dopamine (DA) system which are accompanied by a delayed and protracted degeneration …
dopamine (DA) system which are accompanied by a delayed and protracted degeneration …
Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)
FW Schwaiger, GHB Schmitt, A Horvat… - European Journal of …, 2000 - Wiley Online Library
Nerve injury leads to the release of a number of cytokines which have been shown to play
an important role in cellular activation after peripheral nerve injury. The members of the …
an important role in cellular activation after peripheral nerve injury. The members of the …
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum …
C Rosenblad, D Kirik, B Devaux… - European Journal of …, 1999 - Wiley Online Library
Both glial cell line‐derived neurotrophic factor (GDNF) and its recently discovered congener,
neurturin (NTN), have been shown to excert neuroprotective effects on lesioned nigral …
neurturin (NTN), have been shown to excert neuroprotective effects on lesioned nigral …
Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
C Winkler, H Sauer, CS Lee… - Journal of …, 1996 - Soc Neuroscience
Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neuroprotective
effects on dopamine (DA) neurons in vivo. Here we report long-term rescue of nigral DA …
effects on dopamine (DA) neurons in vivo. Here we report long-term rescue of nigral DA …
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
C Rosenblad, M Grønborg, C Hansen, N Blom… - Molecular and Cellular …, 2000 - Elsevier
The glial cell line-derived neurotrophic factor (GDNF)-family of neurotrophic factors
consisted until recently of three members, GDNF, neurturin, and persephin. We describe …
consisted until recently of three members, GDNF, neurturin, and persephin. We describe …
Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model …
C Rosenblad, A Martinez-Serrano, A Björklund - Neuroscience, 1997 - Elsevier
The ability of intrastriatally-administered glial cell line-derived neurotrophic factor to induce
reinnervation and functional recovery in the partially-lesioned nigrostriatal dopamine system …
reinnervation and functional recovery in the partially-lesioned nigrostriatal dopamine system …
The role of inducible transcription factors in apoptotic nerve cell death
M Dragunow, K Preston - Brain research reviews, 1995 - Elsevier
Recent studies have shown that certain types of nerve cell death in the brain occur by an
apoptotic mechanism. Researchers have demonstrated that moderate hypoxic-ischemic (HI) …
apoptotic mechanism. Researchers have demonstrated that moderate hypoxic-ischemic (HI) …