Proton pump inhibitors (PPIs) marked a before and after in the management of gastric acid‐
related disorders since their introduction to the market in 1989. Due to a novel, highly …

Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there
are concerns about overuse and the numerous reported side-effects. It is uncertain whether …

Background & Aims Proton pump inhibitors (PPIs) have a major impact on gut microbiome
and immune function, which in turn, may increase the risk of inflammatory bowel disease …

Background Antibiotic-induced gut dysbiosis has been associated with colorectal cancer
(CRC) in older adults. This study will investigate whether an association exists between …

METHODS: We performed a nested case-control study in a large, community-based
integrated healthcare setting. Cases were adults with gastric (n= 1,233), colorectal (n …

Epidemiological studies of statin use and liver cancer risk have produced conflicting results.
We examined the association between statin use and risk of primary liver cancer in two large …

Importance In 2019, the US Food and Drug Administration (FDA) received a citizen petition
indicating that ranitidine contained the probable human carcinogenN-nitrosodimethylamine …

Proton pump inhibitors (PPIs) are amongst the most commonly prescribed drugs in infants
and children with the last decades witnessing a dramatic rise in their utilization. Although …

Although proton pump inhibitors (PPIs) are widely used in the treatment of various acid-
related disorders, observational studies have raised concern about an association between …

Background For the past two decades, dispute on whether proton pump inhibitor (PPI) leads
to digestive tract cancer remains, and emerging studies in recent years still demonstrate …