CRISPR-Cas technology has revolutionized biological research and holds great therapeutic
potential. Here, we review CRISPR-Cas systems and their latest developments with an …

Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive
potential for disease modelling and regenerative medicine. However, the limited …

Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease
modeling and the generation of tissue for renal replacement. Long-term application …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …

The capacity of the 3D-organoid cultures to resemble a near-physiological tissue
organization and to mimic–to a certain degree–organ functionality, make organoids an …

Three-dimensional cultured organoids have become a powerful in vitro research tool that
preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …