[HTML][HTML] Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals

F Fiehn, C Beisel, M Binder - Current Opinion in Virology, 2024 - Elsevier
Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis,
with a risk for the development of hepatocellular carcinoma (HCC). Although highly effective …

Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options

S Panneerselvam, C Wilson, P Kumar… - Cell Adhesion & …, 2023 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor
globally and the second most common cause of mortality. HCC develops with complex …

[HTML][HTML] Accelerated aging with HIV occurs at the time of initial HIV infection

EC Breen, ME Sehl, R Shih, P Langfelder, R Wang… - IScience, 2022 - cell.com
Living with HIV infection is associated with early onset of aging-related chronic conditions,
sometimes described as accelerated aging. Epigenetic DNA methylation patterns can …

Hepatocellular organellar abnormalities following elimination of hepatitis C virus

H Aoyagi, H Iijima, ES Gaber, T Zaitsu… - Liver …, 2023 - Wiley Online Library
Background and aims The future development of hepatocellular carcinoma (HCC) in
patients after sustained virologic response (SVR) is an important issue. The purposes of this …

Epigenetic changes affecting the development of hepatocellular carcinoma

E Wolinska, M Skrzypczak - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is a life-threatening disease. Despite many
efforts to understand the exact pathogenesis and the signaling pathways involved in its …

Viral manipulation of the host epigenome as a driver of virus-induced oncogenesis

SHAA Soliman, A Orlacchio, F Verginelli - Microorganisms, 2021 - mdpi.com
Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer
burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms …

HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive …

H Kasai, A Yamashita, Y Akaike, T Tanaka, Y Matsuura… - mBio, 2024 - journals.asm.org
We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression
induces HOX gene expression by impairing histone H2A monoubiquitination via a …

[HTML][HTML] An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and …

Y Hu, X Zhang, Q Li, Q Zhou, D Fang, Y Lu - Computational and Structural …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality. This study aimed
to build a prognostic signature for HCC patients based on immune-related genes (IRGs) and …

[HTML][HTML] The Role of Epigenetic Mechanisms in the Pathogenesis of Hepatitis C Infection

J Żychowska, M Ćmil, P Skórka… - Biomolecules, 2024 - mdpi.com
Hepatitis C virus (HCV) is a hepatotropic virus that can be transmitted through unsafe
medical procedures, such as injections, transfusions, and dental treatment. The infection …

The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection

G Papadopoulou, S Petroulia, E Karamichali… - Cells, 2023 - mdpi.com
Hepatitis C virus (HCV) alters gene expression epigenetically to rearrange the cellular
microenvironment in a beneficial way for its life cycle. The host epigenetic changes induced …