Chronic periapical periodontitis (CAP) is a typical oral disease in which periodontal
inflammation caused by an odontogenic infection eventually leads to bone loss …

Cytokines are an important set of proteins regulating bone homeostasis. In inflammation
induced bone resorption, cytokines, such as RANKL, TNF-α, M-CSF, are indispensable for …

Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic
mutations together with environmental triggers can disable Paneth cell function. Here, we …

Nonalcoholic fatty liver disease (NAFLD) and osteoporosis are two highly prevalent
metabolic diseases. Increasing experimental evidence supports a pathophysiological link …

Objective This study was aimed to reveal the molecular mechanism of bone destruction due
to macrophage polarization leading to during extrapulmonary tuberculosis (EPTB) infection …

Abstract Purpose of Review Patients with diabetes mellitus (DM) are at increased risk of
developing osteopathogenesis and skeletal fragility. The role of the gut microbiota in both …

The microbiome provides resistance to infection. However, the underlying mechanisms are
poorly understood. We demonstrate that colonization with the intestinal bacterium …

Substantial morbidity and mortality are associated with postcardiac arrest brain injury
(PCABI). MicroRNAs (miRNAs) are essential regulators of neuronal metabolism processes …

Background Osteoclasts are key determinant cellular components implicated in the
development and progression of disorders driven by bone damage. Herein, we studied the …

Patients with gastrointestinal diseases frequently suffer from skeletal abnormality,
characterized by reduced bone mineral density, increased fracture risk, and/or joint …