Insulin secretion is a highly dynamic process regulated by various factors including
nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied …

330 The Journal of Clinical Investigation| August 2000| Volume 106| Number 3 ated with a
failure of adequate β-cell mass expansion in the face of insulin resistance. When the …

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

Executive Summary and Recommendations A diagnosis of diabetes or hyperglycemia
should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the …

The intestinally derived hormone glucagon-like peptide 1 (GLP-1)(7-36 amide) has potent
effects on glucose-mediated insulin secretion, insulin gene expression, and β-cell growth …

OBJECTIVE—To investigate whether long-term optimal glycemic control can be achieved
without medication by transient continuous subcutaneous insulin infusion (CSII) and the …

Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin
Sensitivity | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement Oxford …

Controlled clinical trials have shown that optimal glycemic control can prevent the
microvascular complications of type 2 diabetes mellitus; considerable epidemiological data …

One form of maturity-onset diabetes of the young (MODY) results from mutations in a gene,
designated MODY3, located on chromosome 12 in band q24. The present study was …

Known treatments of type 2 diabetes mellitus have limitations such as weight gain, and
hypoglycaemias. A new perspective is the use of incretin hormones and incretin enhancers …