Zimbabwe offers the most recent example of the tragedy that befalls a country and its people
when cholera strikes. The 2008–2009 outbreak rapidly spread across every province and …

Enteric infections, with or without overt diarrhea, have profound effects on intestinal
absorption, nutrition, and childhood development as well as on global mortality. Oral …

Understanding the mechanisms underlying the induction of immunity in the gastrointestinal
mucosa following oral immunization and the cross‐talk between mucosal and systemic …

Defined mutant libraries allow for efficient genome-scale screening and provide a
convenient collection of mutations in almost any nonessential gene of interest. Here, we …

ABSTRACT A cohort of 321 children was followed from birth up to 2 years of age to
determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The …

The gram-negative bacterium Vibrio cholerae releases outer membrane vesicles (OMVs)
during growth. In this study, we immunized female mice by the intranasal, intragastric, or …

The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease
cholera. The gut microbiome, or the native community of microorganisms found in the …

The mucosal surface is the largest route through which pathogens enter the human body. To
control the outbreak of mucosal infectious diseases, we must use our knowledge of the …

Mucosal vaccines are considered the most suitable type of vaccines to combat emerging
and re-emerging infectious diseases because of their ability to induce both mucosal and …

BACKGROUND: Safety and immunogenicity study of an oral, killed, bivalent whole-cell,
cholera vaccine, Shanchol was carried out in Bangladeshi participants. This study was …