The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

The mammary epithelium undergoes profound morphogenetic changes during
development. Architecturally, it comprises two primary lineages, the inner luminal and outer …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is
currently believed that four to six crypt stem cells reside at the+ 4 position immediately above …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

The adult mouse mammary epithelium contains self-sustained cell lineages that form the
inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its …

Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like
phenotype. It has been suggested that this results from an origin in basal breast epithelial …

Background Breast cancer cell lines have been used widely to investigate breast cancer
pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease …

The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic
morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent …

Introduction The organisation of the mammary epithelial hierarchy is poorly understood. Our
hypothesis is that the luminal cell compartment is more complex than initially described, and …