Enzymatic transformations of macromolecular substrates such as DNA repair enzyme/DNA
transformations are commonly interpreted primarily by active-site functional-group chemistry …

The classical 4'-oxonucleoside analogs exhibit interesting biological activities such as
antibiotic, antiviral and antitumor, which are believed to be the result of inhibition of the viral …

We evaluated 4′-[methyl-11C] thiothymidine ([methyl-11C] S-dThd) to obtain a thymidine
analog that might prove simpler to use for imaging DNA synthesis and that might follow the …

An improved large scale synthesis of 1, 4-anhydro-4-thio-d-ribitol (4) from d-ribose has been
accomplished by combining the O-allyl and Op-methoxybenzyl protecting groups …

We report herein a practical synthesis of 4 '-thiothymidine (15) and appropriately protected 2
'-deoxy-4 '-thiocytidine (16),-thioadenosine (27), and-thioguanosine (29) derivatives …

Derivatives of 2′-deoxyuridine that contain fluoroalkyl groups at the C5 position and
derivatives of thymidine that contain fluoroalkyl groups at the N3 position were synthesized …

The search for novel nucleosides has been a major research focus in medicinal chemistry
for several decades, particularly given their proven track record in the treatment of viral …

The reaction of thymidine, 3-mono-, and 3, 3′, 5′-trialkylsubstitued thymidine analogues
with iodine monochloride (ICl) was investigated. Treatment with ICl resulted in rapid …

The synthesis of a thiobutyrolactone as precursor of modified nucleosides is reported from a
fluoroxanthate and a protected allylic alcohol. This approach opens a new and …

Rapidly proliferating cells, such as cancerous cells, show increased reliance on
deoxyribonucleic acid (DNA) salvage pathways for producing nucleotides required for DNA …