A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

Nitric oxide (NO) is one of the 10 smallest molecules found in nature. It is a simple gaseous
free radical whose predominant functions is that of a messenger through cGMP. In …

The increasing understanding of the role of nitric oxide (NO) in cancer biology has
generated significant progress in the use of NO donor-based therapy to fight cancer. These …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53
(mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms …

Free radicals are ubiquitous in our body and are generated by normal physiological
processes, including aerobic metabolism and inflammatory responses, to eliminate invading …

A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of
the inflammatory response, eg, cytokines, free radicals, prostaglandins and growth factors …