Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and
mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the …

Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Mitophagy is a key intracellular process that selectively removes damaged mitochondria to
prevent their accumulation that can cause neuronal degeneration. During mitophagy, PINK1 …

Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-
induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric …