Naphthoquinones and derivatives as potential anticancer agents: An updated review

MM Rahman, MR Islam, S Akash, S Shohag… - Chemico-Biological …, 2022 - Elsevier
One of the leading global causes of death is cancer; even though several treatment methods
have improved survival rates, the incidence and fatality rates remain high. Naphthoquinones …

The relevance and insights on 1, 4-naphthoquinones as antimicrobial and antitumoral molecules: A systematic review

G Navarro-Tovar, S Vega-Rodríguez, E Leyva… - Pharmaceuticals, 2023 - mdpi.com
Natural product derivatives are essential in searching for compounds with important
chemical, biological, and medical applications. Naphthoquinones are secondary …

Oxidative aminotrifluoromethylation of 1, 4-naphthoquinone

L Tang, F Jia, R Yu, X Wei, L Zhang… - The Journal of Organic …, 2024 - ACS Publications
A strategy for convenient and precise oxidative aminotrifluoromethylation of 1, 4-
naphthoquinone with the Togni reagent and amines has been demonstrated via a radical …

Research status of indole-modified natural products

SF Duan, L Song, HY Guo, H Deng, X Huang… - RSC Medicinal …, 2023 - pubs.rsc.org
Indole is a heterocyclic compound formed by the fusion of a benzene ring and pyrrole ring,
which has rich biological activity. Many indole-containing compounds have been sold on the …

[HTML][HTML] Unlocking the potential of 1, 4-naphthoquinones: A comprehensive review of their anticancer properties

E Angulo-Elizari, A Henriquez-Figuereo… - European Journal of …, 2024 - Elsevier
Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

[HTML][HTML] A covalent strategy to target intrinsically disordered proteins: discovery of novel tau aggregation inhibitors

L Petri, P Ábrányi-Balogh, D Vagrys, T Imre… - European Journal of …, 2022 - Elsevier
Intrinsically disordered proteins (IDPs) play important roles in disease pathologies; however,
their lack of defined stable 3D structures make traditional drug design strategies typically …

Molecular docking and anticancer activity of some synthesized 1, 4-naphthoquinone derivatives against human cancer cell line

AAS Abdelaziz, M Nawaz, I Izzeldin… - Journal of Molecular …, 2023 - Elsevier
Abstract A series of 2-amino-4H-naphthopyran-3-carbonitrile (1–16a) derivatives and 2-
amino-4H-naphthopyran-3-carbonitrile (17–19b) derivatives were synthesized and were …

Differential Effect of 4H-Benzo[d] [1,3]oxazines on the Proliferation of Breast Cancer Cell Lines

I Fraire-Soto, JG Araujo-Huitrado… - Current Medicinal …, 2024 - benthamdirect.com
Background A family of 4 H-benzo [d][1, 3] oxazines were obtained from a group of N-(2-
alkynyl) aryl benzamides precursors via gold (I) catalysed chemoselective 6-exo-dig CO …

Copper‐Catalyzed One‐Pot Three‐Component Aminophosphinoylation of 1, 4‐Naphthoquinone

B Wang, W Han, Y Zhang, Z Chen, Y Xia, S Wu… - …, 2024 - Wiley Online Library
A copper‐catalyzed one‐pot three‐component aminophosphinoylation reaction of 1, 4‐
naphthoquinone with disubstituted phosphine oxides and arylamines has been developed …

Visible light-driven and substrate-promoted alkenyltrifluoromethylation of alkenes to synthesize CF 3-functionalized 1, 4-naphthoquinones

L Tang, F Jia, R Yu, L Zhang, Q Zhou - Organic & Biomolecular …, 2025 - pubs.rsc.org
The first example of the visible light-driven and substrate-promoted three-component
alkenyltrifluoromethylation of alkenes is developed. This approach uses easily available …