Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Nonhuman primates are critically important animal models in which to study complex human
diseases, understand biological functions, and address the safety of new diagnostics and …

A major obstacle to achieving long-term antiretroviral (ART) free remission or functional cure
of HIV infection is the presence of persistently infected cells that establish a long-lived viral …

Gut homing CD4+ T cells expressing the integrin α4β7 are early viral targets and contribute
to HIV-1 pathogenesis, likely by seeding the gastrointestinal (GI) tract with HIV. Although …

Timely and accurate assessment and diagnosis are extremely important and beneficial for
all diseases, especially for some of the major human disease, such as cancers …

The advent of immune checkpoint inhibitors has reinvigorated the field of immuno-oncology.
These monoclonal antibody-based therapies allow the immune system to recognize and …

The incorporation of biologically active host proteins into HIV-1 is a well-established
phenomenon, particularly due to the budding mechanism of viral egress in which viruses …

HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in
resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection …

CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent
HIV reservoirs that are established during the very early stages of infection. The tissue …

Dramatic, but uneven, progress in the development of immunotherapies for cancer has
created a need for better diagnostic technologies including innovative non-invasive imaging …