Reassessment of historical clinical trials supports the effectiveness of phage therapy

L Marongiu, M Burkard, UM Lauer… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Phage therapy has become a hot topic in medical research due to the increasing prevalence
of antibiotic-resistant bacteria strains. In the treatment of bacterial infections, bacteriophages …

Bacteriophage therapy against ESKAPE bacterial pathogens: Current status, strategies, challenges, and future scope

M Kulshrestha, M Tiwari, V Tiwari - Microbial Pathogenesis, 2023 - Elsevier
The ESKAPE pathogens are the primary threat due to their constant spread of drug
resistance worldwide. These pathogens are also regarded as opportunistic pathogens and …

[HTML][HTML] A focus on different types of organic particles and their significance in the open ocean carbon cycle

C Baumas, M Bizic - Progress in Oceanography, 2024 - Elsevier
Marine particles are key to the cycling of major elements on Earth and play an important role
in the balance of nutrients in the ocean. Three main categories of marine particles link the …

Further considerations on how to improve phage therapy experimentation, practice, and reporting: Pharmacodynamics perspectives

ST Abedon - Therapy, Applications, and Research, 2022 - liebertpub.com
Phage therapy uses bacterial viruses (bacteriophages) to infect and kill targeted pathogens.
Approximately one decade ago, I started publishing on how possibly to improve upon phage …

Polymer-mediated cryopreservation of bacteriophages

HL Marton, KM Styles, P Kilbride, AP Sagona… - …, 2021 - ACS Publications
Bacteriophages (phages, bacteria-specific viruses) have biotechnological and therapeutic
potential. To apply phages as pure or heterogeneous mixtures, it is essential to have a …

A mechanism-based pathway toward administering highly active N-phage cocktails

NM Smith, TD Nguyen, WH Chin, JT Sanborn… - Frontiers in …, 2023 - frontiersin.org
Bacteriophage (phage) therapy is being explored as a possible response to the
antimicrobial resistance public health emergency. Administering a mixture of different phage …

Automating Predictive Phage Therapy Pharmacology

ST Abedon - Antibiotics, 2023 - mdpi.com
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages.
Because of their ability to act bactericidally, phages increasingly are being employed …

Application of MIDD to accelerate the development of anti-infectives: Current status and future perspectives

WY Mak, Q He, W Yang, N Xu, A Zheng, M Chen… - Advanced Drug Delivery …, 2024 - Elsevier
This review examines the role of model-informed drug development (MIDD) in advancing
antibacterial and antiviral drug development, with an emphasis on the inclusion of host …

Development of an in vitro homeostasis model between airway epithelial cells, bacteria and bacteriophages: a time-lapsed observation of cell viability and …

P Tzani-Tzanopoulou… - Journal of General …, 2022 - microbiologyresearch.org
Bacteriophages represent the most extensive group of viruses within the human virome and
have a significant impact on general health and well-being by regulating bacterial …

Transposable element insertions into the Escherichia coli polysialic acid gene cluster result in resistance to the K1F bacteriophage

KM Styles, RK Locke, LA Cowley, AT Brown… - Microbiology …, 2022 - Am Soc Microbiol
Reviewing the genetics underlying the arms race between bacteria and bacteriophages can
offer an interesting insight into the development of bacterial resistance and phage co …