VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

A Arrigo, E Aragona, F Bandello - Annals of medicine, 2022 - Taylor & Francis
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes
mellitus, representing a major cause of visual impairment in developed countries …

The ErbB/HER family of protein-tyrosine kinases and cancer

R Roskoski Jr - Pharmacological research, 2014 - Elsevier
The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

[PDF][PDF] Progress and challenges of anti-VEGF agents and their sustained-release strategies for retinal angiogenesis

M Xu, R Fan, X Fan, Y Shao, X Li - Drug design, development and …, 2023 - Taylor & Francis
Currently, the treatment for ocular neovascular diseases, including diabetic macular edema
(DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal …

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan‐cancer analysis

H Liu, B Zhang, Z Sun - Cancer communications, 2020 - Wiley Online Library
Background Human epidermal growth factor receptor (EGFR) is an oncogenic gene and one
of top targets of precision therapy in lung cancer with EGFR mutations. Although there are …

Organic nanocarriers for bevacizumab delivery: An overview of development, characterization and applications

ACS Alves, FA Bruinsmann, SS Guterres… - Molecules, 2021 - mdpi.com
Bevacizumab (BCZ) is a recombinant humanized monoclonal antibody against the vascular
endothelial growth factor, which is involved in the angiogenesis process. Pathologic …

Recent Progress in Polymeric Micelle-Enabled Targeted Nanotherapeutics for Diabetic Retinopathy

D Sil, D Kumar, BD Kurmi, M Kumar - Journal of Drug Delivery Science and …, 2024 - Elsevier
Diabetic Retinopathy (DR) is an expanding metabolic complications of diabetes mellitus
(DM) and is the leading cause of blindness in the working population. This disease occurs …

Molecular features of classic retinal drugs, retinal therapeutic targets and emerging treatments

A Arrigo, F Bandello - Pharmaceutics, 2021 - mdpi.com
The management of exudative retinal diseases underwent a revolution due to the
introduction of intravitreal treatments. There are two main classes of intravitreal drugs …

RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis

B Dai, P Zhang, Y Zhang, C Pan… - Oncology …, 2016 - spandidos-publications.com
Mutations in the RNaseH2A gene are involved in Aicardi‑Goutieres syndrome, an autosomal
recessive neurological dysfunction; however, studies assessing RNaseH2A in relation to …

Epithelial membrane protein 2: Molecular interactions and clinical implications

LK Chung, NS Bhatt, C Lagman, PE Pelargos… - Journal of Clinical …, 2017 - Elsevier
Abstract Epithelial membrane protein 2 (EMP2) is a cell surface protein that has recently
emerged as an object of neuro-oncological interest due to its potential to be utilized as a …

Leveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomas

PD St-Coeur, M Touaibia… - Genomics …, 2013 - academic.oup.com
Glioblastoma multiforme (GBM) is the most common adult primary tumor of the central
nervous system. The current standard of care for glioblastoma patients involves a …