Human aldo–keto reductases AKR1C1–AKR1C4 and AKR1D1 play essential roles in the
metabolism of all steroid hormones, the biosynthesis of neurosteroids and bile acids, the …

Aldo-keto reductases (AKRs) are monomeric NAD (P)(H)-dependent oxidoreductases that
play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C …

Androgens play an important role in prostate cancer (PCa) development and progression.
Accordingly, androgen deprivation therapy remains the front-line treatment for locally …

Background: Oxcarbazepine is thought to be better-tolerated and less susceptible to drug–
drug interactions than its predecessor, carbamazepine. Genetic testing for HLA-B* 15: 02 is …

Steroid hormones synchronize a variety of functions throughout all stages of life. Importantly,
steroid hormone-transforming enzymes are ultimately responsible for the regulation of these …

The formation of steroid hormones in peripheral target tissues is referred to as their
intracrine formation. This process occurs in hormone dependent malignancies such as …

Objective Exemestane (EXE) is a potent third-generation aromatase inhibitor used as
endocrine therapy in breast cancer treatment and prevention. Characterization of its …

The aldo-keto reductase (AKR) superfamily is a large family of proteins found across the
kingdoms of life. Shared features of the family include 1) structural similarities such as an …

Background: Studies of alcohol effects in rodents and in vitro implicate endogenous
neuroactive steroids as key mediators of alcohol effects at GABAA receptors. We used a …

Weight gain, when it leads to overweight or obesity, is nowadays one of the major health
problems. ACE, FTO, AKR1C2, TIMP4 and MMP2 genes have been implicated in previous …