Navigating the chiral pool in the total synthesis of complex terpene natural products

ZG Brill, ML Condakes, CP Ting, TJ Maimone - Chemical reviews, 2017 - ACS Publications
The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

Cycloaddition reactions of enoldiazo compounds

QQ Cheng, Y Deng, M Lankelma… - Chemical Society Reviews, 2017 - pubs.rsc.org
Enoldiazo esters and amides have proven to be versatile reagents for cycloaddition
reactions that allow highly efficient construction of various carbocycles and heterocycles …

A Continuum of Progress: Applications of N‐Hetereocyclic Carbene Catalysis in Total Synthesis

J Izquierdo, GE Hutson, DT Cohen… - Angewandte Chemie …, 2012 - Wiley Online Library
N‐Heterocyclic carbene (NHC) catalyzed transformations have emerged as powerful tactics
for the construction of complex molecules. Since Stetter's report in 1975 of the total synthesis …

Application of (4+ 3) cycloaddition strategies in the synthesis of natural products

Z Yin, Y He, P Chiu - Chemical Society Reviews, 2018 - pubs.rsc.org
(4+ 3) Cycloadditions have been widely applied in synthesis, and in this review article, we
summarize some of the more recent applications, including formal (4+ 3) cycloadditions, in …

(−)‐Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

Y Akbulut, HJ Gaunt, K Muraki… - Angewandte Chemie …, 2015 - Wiley Online Library
Current therapies for common types of cancer such as renal cell cancer are often ineffective
and unspecific, and novel pharmacological targets and approaches are in high demand …

Recent advances in Stetter reaction and related chemistry: an update

MM Heravi, V Zadsirjan… - Asian Journal of …, 2020 - Wiley Online Library
The Stetter reaction is actually a special C− C bond forming reaction through a 1, 4‐addition
reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes …

Strategic innovation in the total synthesis of complex natural products using gold catalysis

Y Zhang, T Luo, Z Yang - Natural Product Reports, 2014 - pubs.rsc.org
Covering: 2008 to 2013 Novel organic reactions drive the advance of chemical synthesis in
the same way that enabling technologies drive new scientific discoveries. One area of …

A brief synthesis of (−)-englerin A

Z Li, M Nakashige, WJ Chain - Journal of the American Chemical …, 2011 - ACS Publications
Englerins A and B are guaiane sesquiterpenes that were isolated from the bark of
Phyllanthus engleri, a plant indigenous to east Africa. The englerins consist of a 5-6-5 fused …

Rhodium-catalyzed tandem cyclopropanation/Cope rearrangement of 4-alkenyl-1-sulfonyl-1, 2, 3-triazoles with dienes.

BT Parr, HML Davies - Angewandte Chemie, 2013 - search.ebscohost.com
The article focuses on the study regarding the rhodium-catalyzed tandem cyclopropanation
with dienes. The study involves the palladium-catalyzed cross-coupling of diazoacetates …

Semisynthesis of plant-derived englerin A enabled by microbe engineering of guaia-6, 10 (14)-diene as building block

T Siemon, Z Wang, G Bian, T Seitz, Z Ye… - Journal of the …, 2020 - ACS Publications
Herein, we report a short semisynthesis of the potent transient receptor potential canonical
(TRPC) channel agonist englerin A (EA) and the related guaianes oxyphyllol and orientalol …