Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

Introduction Individual participant data (IPD) systematic reviews and meta-analyses are
often considered to be the gold standard for meta-analysis. In the ten years since the first …

In the antiretroviral therapy (ART) era, serious non-AIDS events (SNAEs) have become the
major causes of morbidity and mortality in HIV-infected persons. Early ART initiation has the …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and
comprise three different isoforms namely PPARα, PPARγ, and PPARβ/δ with PPARβ/δ being …

Introduction: Lipodystrophy is a term used to describe a metabolic complication of fat loss, fat
gain, or a combination of fat loss and gain, which is associated with some antiretroviral …

Weight gain or body fat redistribution are common side effects of many widely used drugs.
Weight gain amounts varying between a few kg to an increase of 10% or more of initial body …

More than 15 years after the introduction of highly active antiretroviral therapy, HIV/HAART-
associated lipodystrophy syndrome still shadows the indisputable efficacy of antiretroviral …

Morphologic and metabolic abnormalities, including subcutaneous adipose tissue wasting,
central adipose tissue accumulation, dyslipidemia and disorders of glucose metabolism are …

The widespread use of combination antiretroviral therapy (cART) has resulted in significantly
reduced deaths from HIV-1 associated complications and opportunistic infections. However …

HIV-associated lipodystrophy syndrome (HALS), comprising metabolic and morphological
alterations, is a known side effect of highly active antiretroviral therapy (HAART). Evidence …