Wearable sensors hold great potential in empowering personalized health monitoring,
predictive analytics, and timely intervention toward personalized healthcare. Advances in …

Aptamers are exciting smart molecular probes for specific recognition of disease biomarkers.
A number of strategies have been developed to convert target–aptamer binding into …

Threose nucleic acid has been considered a potential evolutionary progenitor of RNA
because of its chemical simplicity, base pairing properties and capacity for higher-order …

Chemical modifications are necessary to ensure the metabolic stability and efficacy of
oligonucleotide-based therapeutics. Here, we describe analyses of the α-(l)-threofuranosyl …

Nucleic acids are emerging as powerful and functional biomaterials due to their molecular
recognition ability, programmability, and ease of synthesis and chemical modification …

Threose nucleic acid (TNA) has been considered a potential RNA progenitor in evolution
due to its chemical simplicity and base pairing property. Catalytic TNA sequences with RNA …

Bioinspired and biomimetic nucleobase-containing polymers are a series of polydisperse
nucleic acid analogs, mainly obtaining through highly efficient and scalable step-growth or …

Reprogramming DNA polymerases to synthesize xeno-nucleic acids (XNAs) is an important
challenge that tests current enzyme engineering tools. Here we describe an evolutionary …

Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered
medicinal foods and are frequently used in traditional Chinese medicine due to their …

Functional nucleic acids including aptamers and DNAzymes are a class of valuable
molecular tool for biotechnology. However, DNA and RNA aptamers and catalysts suffer …