Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

S Rayego-Mateos, S Campillo… - Clinical …, 2021 - portlandpress.com
Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

E Hallacli, C Kayatekin, S Nazeen, XH Wang… - Cell, 2022 - cell.com
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

New therapeutic targets in chronic kidney disease progression and renal fibrosis

S Rayego-Mateos, JM Valdivielso - Expert Opinion on Therapeutic …, 2020 - Taylor & Francis
Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial–mesenchymal transition in culture

FAA Ruiter, FLC Morgan, N Roumans… - Advanced …, 2022 - Wiley Online Library
Pluripotent stem cell‐derived kidney organoids offer a promising solution to renal failure, yet
current organoid protocols often lead to off‐target cells and phenotypic alterations …

[HTML][HTML] Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression

C Yu, C Xiong, J Tang, X Hou, N Liu, G Bayliss… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Rationale: The Jumonji domain containing-3 (JMJD3), a specific histone
demethylase for trimethylation on histone H3 lysine 27 (H3K27me3), is associated with the …

Clinical prospect of mesenchymal stromal/stem cell-derived extracellular vesicles in kidney disease: Challenges and the way forward

M Kosanović, B Milutinović, TJ Kutzner, Y Mouloud… - Pharmaceutics, 2023 - mdpi.com
Kidney disease is a growing public health problem worldwide, including both acute and
chronic forms. Existing therapies for kidney disease target various pathogenic mechanisms; …

Metabolic reprogramming and renal fibrosis

X Zhu, L Jiang, M Long, X Wei, Y Hou, Y Du - Frontiers in medicine, 2021 - frontiersin.org
There are several causes of chronic kidney disease, but all of these patients have renal
fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are …

Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications

Y Li, Y Liu, XY Yu, Y Xu, X Pan, Y Sun… - … and Targeted Therapy, 2024 - nature.com
Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

Biomolecular condensates in kidney physiology and disease

G Gao, ES Sumrall, S Pitchiaya, M Bitzer… - Nature Reviews …, 2023 - nature.com
The regulation and preservation of distinct intracellular and extracellular solute
microenvironments is crucial for the maintenance of cellular homeostasis. In mammals, the …

The hyperproliferation mechanism of cholesteatoma based on proteomics: SNCA promotes autophagy-mediated cell proliferation through the PI3K/AKT/CyclinD1 …

M Gao, H Xiao, Y Liang, H Cai, X Guo, J Lin… - Molecular & Cellular …, 2023 - ASBMB
Cholesteatoma is a chronic inflammatory ear disease with abnormal keratinized epithelium
proliferation and tissue damage. However, the mechanism of keratinized epithelium …