Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

The uptake of metal–organic frameworks: A journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

[HTML][HTML] Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell

D Manzanares, V Ceña - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering
therapeutic compounds to cells. Their entry into the cell represents the initial step in this …

Carriers break barriers in drug delivery: endocytosis and endosomal escape of gene delivery vectors

IMS Degors, C Wang, ZU Rehman… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …

Enhanced cisplatin chemotherapy by iron oxide nanocarrier-mediated generation of highly toxic reactive oxygen species

P Ma, H Xiao, C Yu, J Liu, Z Cheng, H Song… - Nano …, 2017 - ACS Publications
Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …

Entry of nanoparticles into cells: The importance of nanoparticle properties

J Zhao, MH Stenzel - Polymer Chemistry, 2018 - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …

Corona composition can affect the mechanisms cells use to internalize nanoparticles

V Francia, K Yang, S Deville, C Reker-Smit, I Nelissen… - ACS …, 2019 - ACS Publications
Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine,
once in contact with biological environments are modified by adsorption of biomolecules on …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

CC Chen, L Liu, F Ma, CW Wong, XE Guo… - Cellular and molecular …, 2016 - Springer
The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …