Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

Simple Summary Here, we review the current state of knowledge in the field of cancer
immunotherapy, focusing on the scientific rationale for the use of oncolytic viruses …

Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are
small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles …

Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-
stranded RNA viruses, which have been engineered for recombinant protein expression and …

Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate
horizontal gene transfer has made them useful tools for gene therapy, vaccine development …

Viral vectors can generate high levels of recombinant protein expression providing the basis
for modern vaccine development. A large number of different viral vector expression systems …

Oncolytic viruses are highly promising for cancer treatment because they target and lyse
tumor cells. These genetically engineered vectors introduce therapeutic or …

Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a
promising new strategy of prodrug delivery, with its main advantages being represented by …

Drug delivery is one of the major challenges in the treatment of central nervous system
disorders. The brain needs to be protected from harmful agents, which are done by the …

The gene therapy is an alternative approach to melanoma treatments due to several drug
resistance that this type of cancer developed and to perform an efficiently in vivo gene …