Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …

Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the
brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on …

Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …

Chemokines secreted by astrocytes play multiple roles in the pathology of Alzheimer's
disease, a chronic inflammation disorder of central nervous system. The level of chemokines …

Chemokines–chemotactic cytokines–are small secreted proteins that attract and activate
immune and non-immune cells in vitro and in vivo. It has been suggested that chemokines …

Aside from its roles in as a classical neurotransmitter involved in regulation of behavior,
noradrenaline (NA) has other functions in the CNS. This includes restricting the …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

The role of chemokines and their receptors in controlling several physiological and
pathological processes has only become evident in the last couple of years. From a sole …

Background Major Depressive Disorder (MDD) is a debilitating mental health condition with
complex etiology, and recent research has focused on pro-inflammatory cytokines and …