The Importance of Mechanical Forces for in vitro Endothelial Cell Biology

E Gordon, L Schimmel, M Frye - Frontiers in Physiology, 2020 - frontiersin.org
Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Between Rho (k) and a hard place: the relation between vessel wall stiffness, endothelial contractility, and cardiovascular disease

S Huveneers, MJAP Daemen, PL Hordijk - Circulation research, 2015 - Am Heart Assoc
Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure,
permeability, and inflammation. As a result, vascular stiffness is a key driver of (chronic) …

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

H Atcha, A Jairaman, JR Holt, VS Meli… - Nature …, 2021 - nature.com
Macrophages perform diverse functions within tissues during immune responses to
pathogens and injury, but molecular mechanisms by which physical properties of the tissue …

Measurement of the uniaxial mechanical properties of healthy and atherosclerotic human coronary arteries

A Karimi, M Navidbakhsh, A Shojaei… - Materials Science and …, 2013 - Elsevier
Atherosclerosis is a common arterial disease which alters the stiffness of arterial wall.
Arterial stiffness is related to many cardiovascular diseases. In this investigation, maximum …

Vascular smooth muscle cell durotaxis depends on extracellular matrix composition

CD Hartman, BC Isenberg… - Proceedings of the …, 2016 - National Acad Sciences
Mechanical compliance has been demonstrated to be a key determinant of cell behavior,
directing processes such as spreading, migration, and differentiation. Durotaxis, directional …

Vascular stiffening and endothelial dysfunction in atherosclerosis

A Hooglugt, O Klatt, S Huveneers - Current opinion in lipidology, 2022 - journals.lww.com
Future research that will define the endothelial contribution to stiffness-related
cardiovascular disease may provide new targets for intervention to restore endothelial …

Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching

P Swiatlowska, B Sit, Z Feng, E Marhuenda… - Science …, 2022 - science.org
Vascular smooth muscle cells (VSMCs) play a central role in the progression of
atherosclerosis, where they switch from a contractile to a synthetic phenotype. Because of …

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

A Schaefer, J Te Riet, K Ritz… - Journal of cell …, 2014 - journals.biologists.com
Chronic vascular inflammation is driven by interactions between activated leukocytes and
the endothelium. Leukocyte β2-integrins bind to endothelial intercellular adhesion molecule …

Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma

G Antonacci, RM Pedrigi… - Journal of the …, 2015 - royalsocietypublishing.org
Plaques vulnerable to rupture are characterized by a thin and stiff fibrous cap overlaying a
soft lipid-rich necrotic core. The ability to measure local plaque stiffness directly to quantify …

Cell-stiffness-induced mechanosignaling–a key driver of leukocyte transendothelial migration

A Schaefer, PL Hordijk - Journal of cell science, 2015 - journals.biologists.com
The breaching of cellular and structural barriers by migrating cells is a driving factor in
development, inflammation and tumor cell metastasis. One of the most extensively studied …