Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Effects of shear stress on endothelial cells: go with the flow

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Y Wang, L Zhang, GR Wu, Q Zhou, H Yue, LZ Rao… - Science …, 2021 - science.org
Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types …

[PDF][PDF] Role of angiogenesis and angiogenic factors in acute and chronic wound healing

TM Honnegowda, P Kumar, EGP Udupa… - Plastic and Aesthetic …, 2015 - researchgate.net
Angiogenesis plays a crucial role in wound healing by forming new blood vessels from
preexisting vessels by invading the wound clot and organizing into a microvascular network …

m7G methyltransferase METTL1 promotes post-ischemic angiogenesis via promoting VEGFA mRNA translation

Y Zhao, L Kong, Z Pei, F Li, C Li, X Sun… - Frontiers in cell and …, 2021 - frontiersin.org
Post-transcriptional modifications play pivotal roles in various pathological processes and
ischemic disorders. However, the role of N7-methylguanosine (m7G), particularly m7G in …

Epigenetic regulation of angiogenesis in development and tumors progression: potential implications for cancer treatment

VM Aspriţoiu, I Stoica, C Bleotu… - Frontiers in cell and …, 2021 - frontiersin.org
Angiogenesis is a multi-stage process of new blood vessel development from pre-existing
vessels toward an angiogenic stimulus. The process is essential for tissue maintenance and …

Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A

Y Zhao, J Hu, X Sun, K Yang, L Yang… - Clinical and …, 2021 - Wiley Online Library
Background Post‐ischemic angiogenesis is critical for blood flow recovery and ischemic
tissue repair. N6‐methyladenosine (m6A) plays essential roles in numerous biological …

Assisted reproductive technologies are associated with cardiovascular remodeling in utero that persists postnatally

B Valenzuela-Alcaraz, F Crispi, B Bijnens… - Circulation, 2013 - Am Heart Assoc
Background—Assisted reproductive technologies (ARTs) have been shown to be
associated with general vascular dysfunction in late childhood. However, it is unknown …

The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation

Y Wang, L Zhang, T Huang, GR Wu… - European …, 2022 - Eur Respiratory Soc
Although DNA methylation has been recognised in the pathogenesis of idiopathic
pulmonary fibrosis (IPF), the exact mechanisms are yet to be fully addressed. Herein, we …

A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation

J Zhong, X Rao, J Deiuliis, Z Braunstein, V Narula… - Diabetes, 2013 - Am Diabetes Assoc
Dipeptidyl peptidase-4 (DDP4) inhibitors target the enzymatic degradation of incretin
peptides and represent a major advance in the treatment of type 2 diabetes. DPP4 has a …