Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Background Inflammation, oxidative stress, and apoptosis contribute to the evolution of
doxorubicin (DOX)‐induced cardiotoxicity. Osteocrin (OSTN) is a novel secretory peptide …

The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

Hydrogen sulfide (H 2 S) is the most recent endogenous gasotransmitter that has been
reported to serve many physiological and pathological functions in different tissues. Studies …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Hydrogen sulfide (H2S) is a gaseous mediator synthesized from cysteine by cystathionine γ
lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments using …