Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Long Covid is a debilitating condition of unknown etiology. We performed multimodal
proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after …

Abstract Coronavirus disease 2019 (COVID-19), the disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a …

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …

During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …