Streptococcus pneumoniae (pneumococcus) is an important pathogen responsible for acute
invasive and non-invasive infections such as meningitis, sepsis and otitis media, being the …

Bacteria possess the ability to evolve varied and ingenious strategies to outwit the host
immune system, instigating an evolutionary arms race. Proteases are amongst the many …

Manganese (Mn) is an essential micronutrient and required cofactor in bacteria. Despite its
importance, excess Mn can impair bacterial growth, the mechanism of which remains largely …

Streptococcus suis is an emerging zoonotic pathogen that causes severe swine and human
infections. Metals are essential nutrients for life; however, excess metals are toxic to …

Otitis media (OM) is an inflammatory disorder in the middle ear. It is mainly caused by
viruses or bacteria associated with the airways. Streptococcus pneumoniae, Haemophilus …

By using a transcriptomic approach, we have elucidated the effect of Ni2+ on the global
gene expression of S. pneumoniae D39 by identifying several differentially expressed …

Previous studies have shown that the transcriptional regulator PsaR regulates the
expression of the PsaR regulon consisting of genes encoding choline binding protein …

In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39
to cysteine. Transcriptome comparison of the D39 wild-type grown at a restricted …

Abstract Cobalt (Co 2+) is an important transition metal ion that plays a vital role in cellular
physiology of bacteria. The role of Co 2+ in the regulation of several genes/operons in …

Quorum Sensing (QS), or bacterial communication by intercellular chemical signaling, is a
process common to many (if not most) bacterial species; yet, it is unclear how QS signaling …