Salicylic acid biosynthesis and metabolism: a divergent pathway for plants and bacteria

AK Mishra, KH Baek - Biomolecules, 2021 - mdpi.com
Salicylic acid (SA) is an active secondary metabolite that occurs in bacteria, fungi, and
plants. SA and its derivatives (collectively called salicylates) are synthesized from …

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: Where we stand

M Shyam, D Shilkar, G Rakshit… - Expert opinion on drug …, 2022 - Taylor & Francis
Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

Synthesis and assessment of the in vitro and ex vivo activity of salicylate synthase (Mbti) inhibitors as new candidates for the treatment of mycobacterial infections

M Mori, G Stelitano, A Griego, LR Chiarelli… - Pharmaceuticals, 2022 - mdpi.com
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most
dangerous infectious diseases worldwide. Because several pathogenic strains of M …

Iron acquisition and metabolism as a promising target for antimicrobials (bottlenecks and opportunities): where do we stand?

G Stelitano, M Cocorullo, M Mori, S Villa… - International Journal of …, 2023 - mdpi.com
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections
is one of the most crucial challenges currently faced by the scientific community …

Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors

G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …

Siderophore producing bacteria as biocontrol agent against phytopathogens for a better environment: A review

CR Deb, M Tatung - South African Journal of Botany, 2024 - Elsevier
Siderophores are iron-chelating compounds produced by various fungi, yeast, bacteria, and
a few plants, having significant potential in biocontrol activities. The success of siderophore …

In silico drug repurposing studies for the discovery of novel Salicyl-AMP ligase (MbtA) Inhibitors

G Rakshit, A Biswas, V Jayaprakash - Pathogens, 2023 - mdpi.com
Tuberculosis (TB) continues to pose a global health challenge, exacerbated by the rise of
drug-resistant strains. The development of new TB therapies is an arduous and time …

Screening approaches and therapeutic targets: The two driving wheels of tuberculosis drug discovery

S Perveen, R Sharma - Biochemical Pharmacology, 2022 - Elsevier
Tuberculosis (TB) is an infectious disease, infecting a quarter of world's population. Drug
resistant TB further exacerbates the grim scenario of the drying TB drug discovery pipeline …

Mycobactin analogues with excellent pharmacokinetic profile demonstrate potent antitubercular specific activity and exceptional efflux pump inhibition

M Shyam, H Verma, G Bhattacharje… - Journal of Medicinal …, 2022 - ACS Publications
In this study, we have designed and synthesized pyrazoline analogues that partially mimic
the structure of mycobactin, to address the requirement of novel therapeutics to tackle the …