BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning. Despite its basic and clinical importance, early human …

We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency
continuum in vivo. Previous studies have generated a number of PSCs with distinct …

In vitro gametogenesis, the process of generating gametes from pluripotent cells in culture,
is a powerful tool for improving our understanding of germ cell development and an …

Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

During female germline development, oocytes become a highly specialized cell type and
form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the …