Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The
absence of functional β-cells leads to hyperglycemia and diabetes, making patients …

With the high prevalence of gastrointestinal disorders, there is great interest in establishing
in vitro models of human intestinal disease and in developing drug-screening platforms that …

Ectopic expression of defined transcription factors can force direct cell-fate conversion from
one lineage to another in the absence of cell division. Several transcription factor cocktails …

Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …

A major challenge in tissue engineering is to develop robust protocols for differentiating ES
and iPS cells to functional adult tissues at a clinically relevant scale. The goal of this study is …

Treatment of type 1 diabetes with insulin injection is expensive, complicated, and
insufficient. While cadaveric islet transplantations coupled with immunosuppressants can …

As one of the largest and most functionally complex organs of the human body, the
intestines are primarily responsible for the breakdown and uptake of macromolecules from …

Morphogen gradients expose cells to different signal concentrations and induce target
genes with different ranges of expression. To determine how the Nodal morphogen gradient …

The elongating mouse anteroposterior axis is supplied by progenitors with distinct tissue
fates. It is not known whether these progenitors confer anteroposterior pattern to the embryo …

Understanding how distinct cell types arise from multipotent progenitor cells is a major quest
in stem cell biology. The liver and pancreas share many aspects of their early development …