As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies
are needed to improve cancer therapy outcomes. Numerous pathways have been shown to …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer due to the
relatively late diagnosis and the limited therapeutic options. Current treatment regimens …

Background Interactions between tumor and microenvironment determine individual
response to immunotherapy. Triple negative breast cancer (TNBC) and hepatocellular …

Background Depression is a common, easily ignored, accompanied disease of gastric
cancer (GC) patients and is often observed with elevated plasma catecholamine levels …

Pancreatic cancer remains one of the most difficult malignancies to treat. Minimal
improvements in patient outcomes and persistently abysmal patient survival rates …

Background Extensive studies have demonstrated the pivotal roles of circular RNAs
(circRNAs) in the occurrence and development of different human cancers. However, the …

Invadopodia, being actin-rich membrane protrusions, play a vital role in tumor cell invasion
and metastasis. Our previous studies have revealed some functions of the DOC-2/DAB2 …

To demonstrate multifaceted contribution of aspartate β-hydroxylase (ASPH) to pancreatic
ductal adenocarcinoma (PDAC) pathogenesis, in vitro metastasis assay and patient derived …

Aspartate/asparagine β‑hydroxylase (AspH) is a type II transmembrane protein that
catalyzes the post‑translational hydroxylation of definite aspartyl and asparaginyl residues in …

Neoadjuvant chemotherapy (NACT) has been established as being an effective treatment
for advanced gastric cancer (GC), while the predictive biomarker of NACT efficacy remains …