Cancer stem cells and chemoresistance: The smartest survives the raid
J Zhao - Pharmacology & therapeutics, 2016 - Elsevier
Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …
Journey of anthraquinones as anticancer agents–a systematic review of recent literature
Anthraquinones are privileged chemical scaffolds that have been used for centuries in
various therapeutic applications. The anthraquinone moiety forms the core of various …
various therapeutic applications. The anthraquinone moiety forms the core of various …
Chemical approaches to targeting drug resistance in cancer stem cells
PA Sotiropoulou, MS Christodoulou, A Silvani… - Drug discovery today, 2014 - Elsevier
Highlights•The CSC concept provided a means to develop novel more effective anti-cancer
strategies.•Human cancers comprised heterogeneous populations of cells including …
strategies.•Human cancers comprised heterogeneous populations of cells including …
G-quadruplex interacting small molecules and drugs: from bench toward bedside
S Müller, R Rodriguez - Expert review of clinical pharmacology, 2014 - Taylor & Francis
G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent
evidence points toward their existence in vivo and their implication in various biological …
evidence points toward their existence in vivo and their implication in various biological …
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial
DM Wolf, C Yau, A Sanil, A Glas, E Petricoin… - NPJ breast …, 2017 - nature.com
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the
biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in …
biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in …
An evaluation in vitro of PARP-1 inhibitors, rucaparib and olaparib, as radiosensitisers for the treatment of neuroblastoma
Background The radiopharmaceutical 131 I-meta-iodobenzylguanidine (131 I-MIBG) is an
effective treatment for neuroblastoma. However, maximal therapeutic benefit from 131 I …
effective treatment for neuroblastoma. However, maximal therapeutic benefit from 131 I …
Synthesis and evaluation of new antitumor 3-aminomethyl-4, 11-dihydroxynaphtho [2, 3-f] indole-5, 10-diones
AE Shchekotikhin, VA Glazunova… - European Journal of …, 2014 - Elsevier
A series of new 3-aminomethyl-4, 11-dihydroxynaphtho [2, 3-f] indole-5, 10-diones 6–13
bearing the cyclic diamine in the position 3 of the indole ring was synthesized. The majority …
bearing the cyclic diamine in the position 3 of the indole ring was synthesized. The majority …
[HTML][HTML] Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra [1, 2-c][1, 2, 5] thiadiazole-6, 11-dione derivatives …
AAA Ali, YR Lee, ATH Wu, VK Yadav, DS Yu… - Arabian Journal of …, 2021 - Elsevier
As part of our research on developing multi-target small molecule anticancer agents, we
designed, synthesized, and biologically evaluated a series of novel diversified analogues …
designed, synthesized, and biologically evaluated a series of novel diversified analogues …
Attenuation of tumor burden in response to rucaparib in lung adenocarcinoma: the contribution of oxidative stress, apoptosis, and DNA damage
M Pérez-Peiró, P Valentí-Serra… - International Journal of …, 2023 - mdpi.com
In cancer, overactivation of poly (ADPribose) polymerases (PARP) plays a relevant role in
DNA repair. We hypothesized that treatment with the PARP inhibitor rucaparib may reduce …
DNA repair. We hypothesized that treatment with the PARP inhibitor rucaparib may reduce …
Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium (II)-arene complexes bearing benzamide derivatives in …
M Pavlović, A Tadić, N Gligorijević, J Poljarević… - Journal of Inorganic …, 2020 - Elsevier
Inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) showed remarkable clinical efficacy
in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3 …
in BRCA-mutated tumors. Based on the rational drug design, derivatives of PARP inhibitor 3 …