▪ Abstract Mouse embryonic stem cells are continuous cell lines derived directly from the
fetal founder tissue of the preimplantation embryo. They can be expanded in culture while …

The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

The remarkable developmental potential and replicative capacity of human embryonic stem
(ES) cells promise an almost unlimited supply of specific cell types for transplantation …

The location and lineage of cells that give rise to endocrine islets during embryogenesis has
not been established nor has the origin or identity of adult islet stem cells. We have …

Demyelination contributes to loss of function after spinal cord injury, and thus a potential
therapeutic strategy involves replacing myelin-forming cells. Here, we show that …

Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

Although the source of embryonic stem (ES) cells presents ethical concerns, their use may
lead to many clinical benefits if differentiated cell types can be derived from them and used …

Stem cells are unique cell populations with the ability to undergo both self-renewal and
differentiation. A wide variety of adult mammalian tissues harbors stem cells, yet “adult” stem …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …